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Year : 2012  |  Volume : 5  |  Issue : 1  |  Page : 7-13

Sample size estimation and power analysis for clinical research studies

1 Department of Biostatistics, National Institute of Animal Nutrition and Physiology, Bangalore, India
2 Department of Immunology and Reumatology, ChanRe Rheumatology and Immunology Center and Research, Bangalore, India

Date of Submission16-Feb-2012
Date of Decision16-Feb-2012
Date of Acceptance07-Mar-2012
Date of Web Publication2-Jul-2012

Correspondence Address:
K P Suresh
Scientist(ss), National Institute of Animal Nutrition and Physiology Adugodi, Bangalore-560030
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-1208.97779

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Determining the optimal sample size for a study assures an adequate power to detect statistical significance. Hence, it is a critical step in the design of a planned research protocol. Using too many participants in a study is expensive and exposes more number of subjects to procedure. Similarly, if study is underpowered, it will be statistically inconclusive and may make the whole protocol a failure. This paper covers the essentials in calculating power and sample size for a variety of applied study designs. Sample size computation for single group mean, survey type of studies, 2 group studies based on means and proportions or rates, correlation studies and for case-control for assessing the categorical outcome are presented in detail.

Keywords: Correlation, odds ratio, power, prevalence, survey, proportions, sample size

How to cite this article:
Suresh K P, Chandrashekara S. Sample size estimation and power analysis for clinical research studies. J Hum Reprod Sci 2012;5:7-13

How to cite this URL:
Suresh K P, Chandrashekara S. Sample size estimation and power analysis for clinical research studies. J Hum Reprod Sci [serial online] 2012 [cited 2023 Feb 8];5:7-13. Available from:

This has been retracted as the sections in the text have been directly copied from a previously published article, entitled, "Issues in outcomes research: An overview of randomization techniques for clinical trials," in pages 215-221, Issue 2, Vol. 45 of Journal of Athletic Training

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84 A Comparison Between the Effect of Combined Chain Exercises Plus Kinesio Taping With Combined Chain Exercises Alone in Knee Osteoarthritis
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86 Improvement in laboratory research: Effects of stocking density, variation and sample size on outcomes of growth studies with shrimp
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87 Psychological impact of the COVID-19 lockdown on Vietnamese community
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88 Oral Health Status and Dental Treatment Needs in Syrian Refugee Children in Zaatari Camp
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89 Perception and adoption of artificial pollination technology in cocoa production: Evidence from Ghana
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91 Hausa translation, cross-cultural adaptation, and assessment of psychometric properties of the Stroke Self-Efficacy Questionnaire
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92 A Locally-Produced Plant-Based Supplement Swathi Savi (SAVI) Enrichment Improves Body Growth, Bone Development, and Immune Functions in Protein Malnourished Mice: Implications for Strategies to Combat Child Malnutrition
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96 Prevalence of gaming disorder: A meta-analysis
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97 The Relationship Between Mindfulness and Happiness in Student-Athletes: The Role of Self-Compassion—Mediator or Moderator?
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103 Effectiveness of Pain Control of Local Anaesthetic Wound Infusion Following Elective Midline Laparotomy: A Randomized Trial
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104 Investigation on chronic tinnitus efficacy of combination of non-repetitive preferred music and educational counseling: a preliminary study
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146 Evaluation of the legal measures taken by dentists in the endodontic treatments in Turkey; A questionnaire survey
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147 The impact of Mental Health of Older People (MHOP) Training Module for Community Health Workers: A preliminary study
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148 To Determine Role of C-reactive Protein Test and Computerised Tomography Scan of Lung in Diagnosis of COVID-19
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150 Normative Reference Standard for Handgrip Strength among Adolescent Students in South Punjab Pakistan: A Cross-Sectional Study
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151 Aging Affects Lower Limb Joint Moments and Muscle Responses to a Split-Belt Treadmill Perturbation
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155 Acute Effect of Riceberry Waffle Intake on Postprandial Glycemic Response in Healthy Subjects
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156 Sensory Acceptability of Dual-Fortified Milled Red and Yellow Lentil (Lens culinaris Medik.) Dal in Bangladesh
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Sleep Patterns and Quality in Omani Adults

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