Journal of Human Reproductive Science
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Year : 2013  |  Volume : 6  |  Issue : 4  |  Page : 227-234
Luteinizing hormone and follicle stimulating hormone synergy: A review of role in controlled ovarian hyper-stimulation

1 Division of Gynaecology, Krishna IVF Clinic, Visakhapatnam, India
2 Department of Pharmacology Medical Affairs, Merck Specialities Private Limited, Mumbai, Maharashtra, India
3 Department of Reproductive medicine, Infertility Institute and Research Centre, Secunderabad, Andhra Pradesh, India
4 Department of Obstetrics, Gynaecology & Infertility, Gunasheela Assisted Reproduction Centre, Bengaluru, Karnataka, India
5 Department of Reproductive Medicine,NOVA IVI Fertility, Kolkata, West Bengal, India
6 Department of Reproductive Medicine,Prashanth Fertility Research Centre, Chennai, India
7 Department of Obstetrics, Gynaecology & Reproductive Medicine, Womens Center and Hospitals, Coimbatore, Tamil Nadu, India
8 Department of Infertility, Akanksha IVF, Anand, Gujarat, India
9 Department of Assisted Reproduction, Fertility Associates, Mumbai, Maharashtra, India

Correspondence Address:
Gottumukkala Achyuta Rama Raju
Krishna IVF Clinic, ZP Junction, Maharanipeta, Visakhapatnam, Andhra Pradesh
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Source of Support: Advisory board meetings supported by Merck Specialties Private Limited, Conflict of Interest: This review article is the result of a series of advisory board meetings supported by Merck Specialties Private Limited

DOI: 10.4103/0974-1208.126285

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Luteinizing hormone (LH) in synergy with follicle stimulating hormone (FSH) stimulates normal follicular growth and ovulation. FSH is frequently used in assisted reproductive technology (ART). Recent studies have facilitated better understanding on the complementary role of the LH to FSH in regulation of the follicle; however, role of LH in stimulation of follicle, optimal dosage of LH in stimulation and its importance in advanced aged patients has been a topic of discussion among medical fraternity. Though the administration of exogenous LH with FSH is obligatory for controlled ovarian stimulation in patients with hypogonadotropic hypogonadism, there is still a paucity of information of its usage in other patient population. In this review we looked in to the multiple roles that LH plays complementary to FSH to better understand the LH requirement in patients undergoing ART.

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