Journal of Human Reproductive Science
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ORIGINAL ARTICLE Table of Contents   
Year : 2017  |  Volume : 10  |  Issue : 3  |  Page : 173-177
A study of controlled ovarian stimulation with clomiphene citrate or letrozole in combination with gonadotropins and IUI in unexplained infertility

1 Mahatma Gandhi Medical College and Research Institute, Puducherry, India
2 Department of Obstetrics and Gynaecology, Lady Hardinge Medical College and SSKH, New Delhi, India
3 Department of Biochemistry, Lady Hardinge Medical College and SSKH, New Delhi, India

Correspondence Address:
Madhusmita Hembram
Asst. Professor, Mahatma Gandhi Medical College and Research Institute, 3F, Type II Staff Quarters, Puducherry - 607 403
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jhrs.JHRS_120_16

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Aim: To compare the effect of clomiphene citrate (CC) + human menopausal gonadotropin (hMG) with letrozole + hMG on size, number of follicles, endometrial thickness, serum levels of oestradiol and progesterone and pregnancy rate. Settings and Design: Non-randomised interventional study. Patients and Methods: A total number of 60 patients in the age group of 20–35 years with unexplained infertility were divided into two groups, 30 in each. Group A received CC + hMG and group B received letrozole + hMG. In both the groups, ovulation was triggered by hCG followed by intrauterine insemination. Results: The number of follicles on day 8 were significantly higher in the CC + hMG group than that in the letrozole + hMG group. Serum oestradiol level was significantly higher in the CC + hMG group on day 10 and on the day of hCG administration. Pregnancy rate in the CC + hMG group was 23.3% and 13.3% in the letrozole + hMG group. Conclusion: The sequential protocol was cost-effective. CC + hMG could be a preferred ovarian stimulation protocol in couples with unexplained infertility with the added advantage of having no significant complications in properly monitored cycles.

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