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| ORIGINAL ARTICLE |
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| Year : 2020 |
Volume
: 13 | Issue : 1 | Page
: 38-45 |
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Thymus vulgaris attenuates myleran-induced reproductive damage by decreasing oxidative stress and lipid peroxidation in male rats
Mohammad Reza Salahshoor1, Amir Abdolmaleki1, Azita Faramarzi2, Arash Ziapour3, Shiva Roshankhah1
1 Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
3 Department of Health Education and Health Promotion, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
Correspondence Address:
Dr. Shiva Roshankhah
Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah
Iran
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jhrs.JHRS_134_19
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Context: Thymus vulgaris is an herbal with potent antioxidant and it has been shown to have beneficial effects during short-term administration. Myleran (MYL) is used for treatment of certain types of tumors. MYL produces free radicals and induces disturbance in sperm parameters. Aims: This study is designed to assess the effects of T. vulgaris against damage to the male rats' reproductive features induced by MYL. Subjects and Methods: Sixty-four male Wistar rats were randomly assigned into eight groups: control group; MYL (10 mg/kg) group; T. vulgaris groups (4.5, 9, and 18 mg/kg); and MYL (10 mg/kg) + T. vulgaris groups (4.5, 9, and 18 mg/kg; separately). Treatments were administered daily intraperitoneal injection for 60 days. Total antioxidant capacity, sperm factors, malondialdehyde (MDA), testosterone, and germinal layer height were analyzed. Results: Whole variables of MYL group decreased signifcantly compared to the control group (P < 0.05) except MDA level (which increased). The T. vulgaris and T. vulgaris + MYL treatments in all doses increased all parameters significantly except MDA level (which decreased) compared to the MYL group (P < 0.05). No significant modifications were observed in all T. vulgaris groups compared to the control group (P > 0.05). Conclusions: T. vulgaris reduces the poisonous properties of MYL on male reproductive factors.
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