|
| CASE REPORT |
 |
|
|
| Year : 2020 |
Volume
: 13 | Issue : 1 | Page
: 68-70 |
|
Complex chromosomal rearrangement: A case report to emphasize the need for parental karyotyping and genetic counseling
Prachi Sinkar, Sneha Ramesh Devi
Department of Genetics, Thyrocare Technologies Limited, Navi Mumbai, Maharashtra, India
Correspondence Address:
Ms. Sneha Ramesh Devi
Department of Genetics, Thyrocare Technologies Limited, Plot No. D37/1, TTC Industrial Area, MIDC, Turbhe, Navi Mumbai - 400 703, Maharashtra
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jhrs.JHRS_145_19
|
|
|
Complex chromosomal rearrangements (CCRs) are rare structural rearrangements which involve at least three or more chromosomal breaks. The present report emphasizes the significance of parental karyotyping and the need of genetic counseling for couples with bad obstetric history (repeated abortions/miscarriages). The report includes the cytogenetic assessment of the proband and the mother, carried out at our accredited laboratory. The karyotype analysis of the proband revealed an apparently balanced translocation, identified to have been familially inherited from the mother having CCRs with double two-way translocations involving four chromosomes.
|
|
|
|
| [FULL TEXT] [PDF]* |
|
 |
|
|
|
