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LETTER TO EDITOR |
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| Year : 2021 | Volume
: 14
| Issue : 3 | Page : 325 |
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Do basal luteinizing hormone and luteinizing hormone/follicle-stimulating hormone ratio have significance in prognosticating the outcome of In vitro fertilization cycles in polycystic ovary syndrome?
Pathum Sookaromdee1, Viroj Wiwanitkit2
1 Private Academic Consultant Center, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India
| Date of Submission | 17-Jun-2021 |
| Date of Decision | 20-Jul-2021 |
| Date of Acceptance | 02-Aug-2021 |
| Date of Web Publication | 28-Sep-2021 |
Correspondence Address:
Dr. Pathum Sookaromdee
Private Academic Consultant, Bangkok
Thailand
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jhrs.jhrs_87_21
How to cite this article:
Sookaromdee P, Wiwanitkit V. Do basal luteinizing hormone and luteinizing hormone/follicle-stimulating hormone ratio have significance in prognosticating the outcome of In vitro fertilization cycles in polycystic ovary syndrome?. J Hum Reprod Sci 2021;14:325 |
How to cite this URL:
Sookaromdee P, Wiwanitkit V. Do basal luteinizing hormone and luteinizing hormone/follicle-stimulating hormone ratio have significance in prognosticating the outcome of In vitro fertilization cycles in polycystic ovary syndrome?. J Hum Reprod Sci [serial online] 2021 [cited 2021 Nov 27];14:325. Available from: https://www.jhrsonline.org/text.asp?2021/14/3/325/326927 |
Dear Editor,
We would like to share ideas on the publication “Do basal luteinizing hormone and luteinizing hormone/follicle-stimulating hormone (LH/FSH) ratio have significance in prognosticating the outcome of in vitro fertilization (IVF) cycles in polycystic ovary syndrome?” Singh et al. noted that “The elevated basal day 2/3 LH and LH/FSH ratio do not impair the outcome of GnRH antagonist protocol treated IVF/intracytoplasmic sperm injection cycles in polycystic ovary syndrome women.[1]” Regarding the diagnostic value of basal day 2/3 LH and LH/FSH ratio, there are many confounding factors that might affect the result. First, certain genetic polymorphisms can have an effect. In a report by Deswal et al., luteinizing hormone and LH receptor gene polymorphisms played important role in determining LH and LH/FSH ratio.[2] Furthermore, assay interference might occur and result in aberrant LH and LH/FSH ratio.[3] Segal et al. reported that heterophile antibodies are examples of those interferences.[3]
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
 References | |  |
| 1. | Singh N, Mishra N, Dogra Y. Do basal luteinizing hormone and luteinizing hormone/follicle-stimulating hormone ratio have significance in prognosticating the outcome of in vitro fertilization cycles in polycystic ovary syndrome? J Hum Reprod Sci 2021;14:21-7.  [Full text] |
| 2. | Deswal R, Nanda S, Dang AS. Association of luteinizing hormone and lh receptor gene polymorphism with susceptibility of polycystic ovary syndrome. Syst Biol Reprod Med 2019;65:400-8. |
| 3. | Segal DG, DiMeglio LA, Ryder KW, Vollmer PA, Pescovitz OH. Assay interference leading to misdiagnosis of central precocious puberty. Endocrine 2003;20:195-9. |
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