Journal of Human Reproductive Science
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Year : 2021  |  Volume : 14  |  Issue : 4  |  Page : 327-328

Editorial commentary

Department of Reproductive Medicine, Shreyas Hospital and Sushrut Assisted Conception Clinic, Kolhapur, Maharashtra, India

Date of Submission24-Dec-2021
Date of Decision24-Dec-2021
Date of Acceptance24-Dec-2021
Date of Web Publication31-Dec-2021

Correspondence Address:
Dr. Padma Rekha Jirge
Department of Reproductive Medicine, Shreyas Hospital and Sushrut Assisted Conception Clinic, 2013E, Rajarampuri, Kolhapur - 416 008, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jhrs.jhrs_187_21

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How to cite this article:
Jirge PR. Editorial commentary. J Hum Reprod Sci 2021;14:327-8

How to cite this URL:
Jirge PR. Editorial commentary. J Hum Reprod Sci [serial online] 2021 [cited 2022 Nov 28];14:327-8. Available from:

Welcome to the last issue of the year and warm wishes for the New Year! This issue comes with two narrative reviews, twelve original articles, one case series and three case reports.

The two review articles provide important insight into the recent progress in the laboratory aspects of assisted reproduction. The review by Parikh et al. discusses the evolution of pre-implantation diagnosis and its role in the diagnosis of monogenic disorders in the preimplantation embryos. A review by Pai et al. provides a current perspective of oocyte cryopreservation including its expanding indications.

An experimental study by Pujianto et al. evaluates the association between expression of a particular gene, CD52 and sperm maturation in mice testes. A retrospective analysis by Khan et al. evaluates the common causes of male factor infertility in an Indian fertility clinic and the impact of using WHO 2010 reference criteria for semen analysis on the diagnosis of male infertility. An original article by Kljajic et al. looks at the semen parameters in volunteers who follow a vegan diet compared to those following no dietary restrictions. This study once again draws our attention to the complex association between lifestyle and health of gametes.

A large retrospective study by Gunasheela et al. identifies that a large proportion of Indian infertile women under the age of 35 years attending a fertility clinic have reduced ovarian reserve. Another study by Palgamkar et al., retrospectively compares the data on anti-Mullerian hormone (AMH) in infertile women from a large diagnostic laboratory database with Indian fertile women and Caucasian women; and provides information on the magnitude of decline in AMH values with age. The limitations of both the studies are highlighted by the authors in respective articles. It is important to exercise due caution while generalising the results of these studies to the population at large. A prospective cohort study by Antonisamy et al. evaluates role of laparoscopy in those with abnormal findings on hysterosalpingogram. Another adequately powered prospective study by Naredi et al. evaluates the beneficial role of 3D ultrasonograpy in comparison to hysteroscopy for pre-IVF assessment.

A retrospective cohort study by Kahyaoglu et al. evaluates the impact of an early versus late start of GnRH antagonist in IVF in poor responders. Another retrospective cohort study by Mitra et al. evaluates the association between preovulatory serum concentrations of sex steroids and IVF outcomes. A study by Ranganath et al. provides important insights into the temporal relationship between in-vitro maturation of GV oocytes from women with PCOS and timing of ICSI to optimise embryo utilization.

A case-control study by Chakraborty et al. comparing couples with recurrent pregnancy loss to fertile controls, identifies the spectrum of chromosomal abnormalities in such individuals. A retrospective study by Joshi et al. looks at the common varieties of Mullerian abnormalities in infertile women and their reproductive outcome.

A case report by Mantravadi et al. of a 46 XX testicular disorder of sex development draws our attention to the importance of a multidisciplinary management of such a sensitive diagnosis. A case series by Al-Rshoud et al. evaluates the role of hysteroscopy during IVF when previously undiagnosed endometrial polyps are noted during ovarian stimulation. Patel et al. report the application of drug free in-vitro activation in a woman with primary ovarian insufficiency. Tandulwadkar et al. report the use of platelet rich plasma and bone marrow derived stem cells in combination, for the management of Asherman's syndrome in an infertile woman to achieve pregnancy.

It is important to note that cohort studies provide the best information about the causal association between risk factors and outcome or disease of interest in comparison to all other types of observational studies. Minimising the effect of chance with adequate sample size, measures to avoid bias, adjusting for confounders with the use of appropriate statistical analysis; and correct interpretation of the study findings are all important steps to improve internal and possibly external validity of such studies. In this issue, I and the entire editorial team gratefully acknowledge all the reviewers who have dedicated their valuable time during the year to critically appraise the submitted manuscripts and improve the quality of those which have been published.

Best wishes,


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