Journal of Human Reproductive Sciences

: 2011  |  Volume : 4  |  Issue : 1  |  Page : 34--38

Do symptomatic endometriosis and uterine fibroids appear together?

Outi Uimari, Ilkka Järvelä, Markku Ryynänen 
 Obstetrics and Gynecology Clinic, Oulu University Hospital, Oulu, Finland

Correspondence Address:
Outi Uimari
Department of Obstetrics and Gynaecology, Oulu University Hospital, PL 24,90029 OYS


Objectives : Endometriosis and uterine fibroids are common gynecological disorders in fertile women. It has been suggested that these two disorders may be associated with each other. In this study, we tested whether this connection exists. In addition, we wanted to evaluate whether they both affect fertility independently of each other. Materials and Methods : The prevalence of endometriosis and uterine fibroids was investigated in three groups of patients: Symptomatic patients requiring surgery either for endometriosis (n=182), or for uterine fibroids (n=240) and asymptomatic patients undergoing laparoscopic sterilization (n=183). The prevalences were examined in three age groups: 35-39 yrs, 40-44 yrs and ≥ 45 yrs. The significance of both diagnoses on fertility was assessed using logistic regression analysis. Results :Uterine fibroids were detected in 25.8% (47/182) of patients with endometriosis. Endometriosis was detected in 19.6% (47/240) of patients with uterine fibroids. 5.5% (10/183) women undergoing sterilization had endometriosis and 19.3% (17/183) had uterine fibroids. Both uterine fibroids and endometriosis were, independently of each other, related to subfertility (OR, 95% CI: 3.8, 2.3-6.5; 6.8, 4.0-11.6, respectively). Conclusions : The results suggest that symptomatic endometriosis appears together with symptomatic uterine fibroids. Both diseases seem to decrease female fertility independently of each other.

How to cite this article:
Uimari O, Järvelä I, Ryynänen M. Do symptomatic endometriosis and uterine fibroids appear together?.J Hum Reprod Sci 2011;4:34-38

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Uimari O, Järvelä I, Ryynänen M. Do symptomatic endometriosis and uterine fibroids appear together?. J Hum Reprod Sci [serial online] 2011 [cited 2022 Jul 3 ];4:34-38
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Endometriosis and uterine fibroids are common gynecological disorders in fertile women. Uterine fibroids are estimated to occur in 33-77% of women during their reproductive years. [1],[2] Even though most fibroids are asymptomatic, they are still the most common reason for hysterectomy. [2],[3],[4],[5],[6] The symptoms are related to their size, number and location in the uterus. Common symptoms are menorrhagia, pelvic pressure or pain and urinary symptoms. [2],[4],[7] The incidence of endometriosis is even more difficult to state because the exact diagnosis requires invasive intervention. [8],[9] Within symptomatic women who have had surgery, the incidence has varied between 2 and 18% [10],[11] The symptoms of endometriosis are chronic pelvic pain, dysmenorrhea, menorrhagia, vibration pain, dyspareunia and dysuria. The proportion of asymptomatic women is significant. [8],[9],[10],[12] Both endometriosis and uterine fibroids may cause infertility. [10],[13],[14],[15]

It has been suggested that these two disorders may be associated with each other and that their etiology has some similarities. [16],[17] Both these diseases are steroid hormone-dependent [1],[2],[3],[11],[12],[18],[19] and they act similarly under the influence of estrogen. [20],[21],[22] In one previous study, women with uterine fibroids were reported to have endometriosis more often than those without fibroids. [23] We wanted to test here whether this connection between uterine fibroids and endometriosis exists. In addition, if the connection seems to be apparent, we wanted to evaluate whether they both affect female fertility independently of each other.

 Materials and Methods

The study was approved by the Ethics Committee of the Oulu University Hospital. We retrospectively studied the hospital records of patients operated on for endometriosis or uterine fibroids (the study groups) or sterilization (the control group) between the years 1990 and 2005 at the Department of Obstetrics and Gynecology, Oulu University Hospital. The search was made for the hospital records based on the diagnosis numbers for endometriosis, uterine fibroids and birth control planning, and on the operation numbers for explorative laparoscopy, laparoscopic excision of peritoneum lesion, abdominal and laparoscopical hysterectomy and sterilization. The subjects undergoing sterilization had no symptoms of endometriosis or uterine fibroids. Only subjects with complete hospital records were included. The diagnosis of endometriosis was based on the pelvic view during laparoscopic sterilization. The diagnosis of fibroids was based on a preoperative transvaginal ultrasonographic examination.

Subjects aged 35 years or older at the time of operation were included. This age limit was chosen because endometriosis has its highest incidence during the early fertile years and it tends to disappear after ovarian function declines. [10] Fibroids, on the contrary, tend to appear more frequently in the late fertile years and they do not disappear after menopause as endometriosis does. [7] The study design is clarified in [Figure 1].{Figure 1}

The association of the diseases was analyzed as follows: The presence of endometriosis, uterine fibroids, or both occurring together was analyzed in all groups. Then an analysis was made among different age groups in the fibroid group and the control group (comparison 1) and between the endometriosis group and the control group (comparison 2). The endometriosis group comprised 182 patients, the uterine fibroid group 240 patients, and the control group 183 patients [Table 1],[Figure 1]. Since 47 patients had both conditions they were included in both disease groups. The comparisons are made within the disease group and the control group, so this does not disturb the analysis.{Table 1}

Statistical analysis

Departure from a normal distribution was assessed using the Kolmogorov-Smirnov test. Paired t-tests were used for normally distributed data, and the Mann-Whitney test (the signed-rank) for skewed data. Proportions were compared by the χ2 test. P<0.05 was considered statistically significant. All values given are the mean±standard deviation (SD). The patients were divided into subgroups according to their age. The age-groups were patients age 35-39, 40-44 and 45 years and older [Table 2].{Table 2}

A logistic regression analysis was used to identify independent factors affecting parity, which here reflects fertility status. Parity was assessed as either having no deliveries or having at least one delivery. Only statistically significant factors were included in the final model. The Hosmer-Lemeshow goodness-of-fit statistic was used to assess the final model. The factors selected for the final analysis were diagnosis of endometriosis and diagnosis of uterine fibroids at the time of operation. All factors were treated as dichotomous variables: Existence of endometriosis or no endometriosis; existence of fibroids or no fibroids. Statistical analysis was performed using SPSS for Windows 12.01 (SPSS Inc., Chicago, IL).


Comparison 1: Fibroid group vs control group

In the fibroid group, 19.6% (47/240) of the patients and 5.5% (10/183) of the control group had endometriosis. The mean difference of the prevalence between the groups was 14.1% (95%CI 8.1-20.1%).

The comparison in different age groups revealed that the prevalence of endometriosis was increased among fibroid patients compared to the control group in the age groups 35-39 and 40-44: 37.0 vs. 6.8% (difference 30.2%, 95% CI 11.3-49.2%) and 34.0 vs. 4.6% (difference 29.4%, 95% CI 15.6-43.3%), respectively [Figure 2]. After age 45 the prevalence of endometriosis decreased remarkably in the fibroid group, from 34.0 to 12.3% (difference 21.7%, 95% CI 7.7-35.8%).{Figure 2}

There were fewer deliveries in the fibroid group than in the control group [Table 3]. Patients with fibroids had a slightly higher BMI than the patients in the control group, 25.5 kg/m 2 vs 24.6 kg/m 2 (P<0.05).{Table 3}

Comparison 2: Endometriosis group vs control group

In the endometriosis group, 25.8% (47/182) of the patients and 9.3% (17/183) of the control group had fibroids. The mean difference of the prevalence between the endometriosis and control groups was 16.5% (95% CI 8.9-24.2%).

The difference in the prevalence of uterine fibroids in the endometriosis and control group remained stable with advanced female age. The prevalence of uterine fibroids in the endometriosis group increased significantly with advancing age, from 14.1% in age group 35-39 to 46.5% in the age group over 45 (difference 32.4%, 95% CI 15.5-49.4%) [Figure 3].{Figure 3}

There were fewer deliveries in the endometriosis group than in the control group [Table 3]. There was not a statistically significant difference in BMI between these groups.

In the disease groups, there were altogether 47 patients with both conditions. There were no such cases in the control group.

Logistic regression analysis

Since the prevalence of endometriosis and fibroids seemed to coincide, we wanted to test whether they both are independent factors associated with subfertility. We used logistic regression analysis, in which nulliparity at the time of operation was determined as subfertility [Table 4]. Data fitted the logistic regression analysis, as indicated by the Hosmer-Lemeshow goodness-of-fit test. Both endometriosis and fibroids proved to be independent factors associated with nulliparity.{Table 4}


Our study suggests that symptomatic endometriosis and symptomatic uterine fibroids appear together. Almost 20% of patients with symptomatic fibroids also had endometriosis. On the other hand, 26% of patients with symptomatic endometriosis also had fibroids. In the control group, none of the patients had both endometriosis and uterine fibroids. Despite the fact that the prevalence of endometriosis and fibroids seemed to coincide, they both were independent factors associated with subfertility in this data set.

Similarly to our results, Hemmings et al. [23] found that patients operated on for endometriosis had fibroids more often than those without endometriosis, and this was suggested to be due to hormone dependency and changes in intrauterine pressure during menses leading to increased retrograde menstrual flow. In a recently published study a majority of symptomatic uterine fibroid patients were also diagnosed with endometriosis. [24] There is a hypothesis that a hyperestrogenic state might have a role in the development of both fibroids and endometriosis. It seems that uterine fibroid cells significantly express aromatase, resulting in elevated tissue concentrations of estrogens in fibroid nodules compared to the surrounding myometrium. [19] Similar to uterine fibroids, endometriotic tissue has been demonstrated to express aromatase and to produce estrogen independently of the ovaries. [19] There are two case reports of rapid growth of both fibroids and endometriosis, and this has been suggested to be a result of a hyperestrogenic state. [21],[22] In addition, the role of estrogens is supported by the fact that neither fibroids nor endometriosis appear before the age of onset of fertility, and during the menopause the symptoms of both diseases diminish. [7]

Women with endometriosis and uterine fibroids had fewer pregnancies and deliveries than the subjects in the control group. It is well-known that the prevalence of both diseases is increased among patients seeking infertility treatments, although it is not clear how these diseases cause infertility. [13],[15],[25] Because our results indicated the connection between the prevalences of endometriosis and fibroids, we wanted to evaluate whether these diseases were independently associated with subfertility or not. According to the National Institute for Health and Welfare, 90% of Finnish women in 2007 delivered their first child before the age of 35 years. Since all patients in our data set were 35 years or older, we determined subfertility as having no deliveries by the time of their operation.

Our analysis revealed that both the diagnosis of endometriosis and of uterine fibroids were independently associated with nulliparity, suggesting that the diagnosis of either one seems to be related to subfertility. The causal relationship between endometriosis and reduced fertility is undetermined, although the prevalence of endometriosis among infertile women is proven to be significantly higher. [15] Our results concerning this relationship go along with the previous results. Those patients who were nulliparous had endometriosis 6.8 times more often than those who had at least one delivery.

Women with uterine fibroids of any location in the uterus have lower rates for clinically diagnosed pregnancies, implantation, and deliveries, and their spontaneous abortion rate is higher. Especially submucosal fibroids have a relation to these rates, but intramural fibroids do as well. The size of fibroids does not seem to have a role in fertility outcomes. [13] Our results were similar. The nulliparous patients had uterine fibroids 3.8 times more often than those who had at least one delivery. Due to the lack of information, we were not able to analyze subfertility due to fibroid location and size.

The prevalence of endometriosis and uterine fibroids is very difficult to examine, because they both tend to have an asymptomatic nature. To diagnose either fibroids or endometriosis, a broader examination than a basic doctor's check-up is required. Uterine fibroids are diagnosed by a standard ultrasonographic examination [2] and endometriosis by a laparoscopic examination. [8] This means that the selection of patients for the control group in this kind of study setting is challenging. [26] Because the reliable diagnosis of endometriosis requires laparoscopy, the best available group for controls consisted of patients undergoing laparoscopy for tubal sterilization. In addition, very few women seek for tubal sterilization after the age of 45, which explains the low number of controls in our study in this age group.

Another challenge in studying endometriosis and uterine fibroids together is the age of the patients. The diagnostic ages differ from each other. The lower age limit was therefore set at 35 years, so that endometriosis would still exist and fibroids, on the other hand, would have already started to appear. There is, however, a possibility that a patient could have had endometriosis earlier and, when fibroids were diagnosed the endometriosis would have had dried out.

In conclusion, the present study showed an association between the prevalence of symptomatic endometriosis and symptomatic uterine fibroids in women aged 35 years or more. Both of these diseases seem to be related to increased subfertility independently of each other.


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