Journal of Human Reproductive Sciences

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 5  |  Issue : 3  |  Page : 248--251

Progesterone supplementation in women with otherwise unexplained recurrent miscarriages


Munawar Hussain1, Samawal El-Hakim2, David J Cahill3 
1 St. Michael's Hospital, University Hospitals Bristol NHS Trust; Bristol Centre for Reproductive Medicine, University of Bristol, United Kingdom
2 Department of Obstetrics and Gynaecology and IVF Sulaiman Al-Habib Group of Hospitals, Qassim, Saudi Arabia
3 St. Michael's Hospital, University Hospitals Bristol NHS Trust; Academic Unit of Obstetrics and Gynaecology, School of Clinical Sciences, University of Bristol, United Kingdom

Correspondence Address:
Munawar Hussain
Subspecialty Training Fellow, Reproductive Medicine and Surgery, St. Michael«SQ»s Hospital, University Hospitals Bristol NHS Trust, Bristol, BS2 8EG
United Kingdom

Context: Recurrent miscarriages, the loss of three or more consecutive intrauterine pregnancies before 20 weeks of gestation with the same partner, affect 1%-1.5% of the pregnant population. The inadequate secretion of progesterone in early pregnancy has been proposed as a cause of recurrent miscarriages. Aims: The aim was to investigate the efficacy of progesterone supplementation in patients with unexplained recurrent miscarriages. Settings And Design: This was a 9-year cohort study of women with otherwise unexplained recurrent miscarriages who attended a recurrent miscarriage clinic in a tertiary care university hospital. Subjects and Methods: Women with at least three unexplained recurrent miscarriages were included in the study. They were divided into three groups according to their initial and 48-h repeat progesterone levels. For women with inadequate endogenous progesterone secretion, natural progesterone vaginal pessaries 400 mg 12-hourly were offered until 12 weeks gestation. Statistical Analysis: Proportions and 95% confidence intervals calculated for categorical variables and the chi-square test were used to show statistical significance. Medians and ranges were calculated for noncontinuous variables. Results: Pregnancy cycles (n = 203) were analyzed to examine the miscarriage rate following progesterone supplementation. Overall live birth and miscarriage rates were 63% and 36%, respectively. When analyzed by the number of previous miscarriages there was a reduction in the miscarriage rate following progesterone supplementation in women with 4 previous miscarriages when compared with historical data. Conclusions: Progesterone supplementation may have beneficial effects in women with otherwise unexplained recurrent miscarriages.


How to cite this article:
Hussain M, El-Hakim S, Cahill DJ. Progesterone supplementation in women with otherwise unexplained recurrent miscarriages.J Hum Reprod Sci 2012;5:248-251


How to cite this URL:
Hussain M, El-Hakim S, Cahill DJ. Progesterone supplementation in women with otherwise unexplained recurrent miscarriages. J Hum Reprod Sci [serial online] 2012 [cited 2022 Sep 26 ];5:248-251
Available from: https://www.jhrsonline.org/article.asp?issn=0974-1208;year=2012;volume=5;issue=3;spage=248;epage=251;aulast=Hussain;type=0