Journal of Human Reproductive Sciences

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 8  |  Issue : 3  |  Page : 146--150

Pregnancy outcome of assisted reproductive technology cycle in patients with hypogonadotropic hypogonadism


Monna Pandurangi, M Tamizharasi, N Sanjeeva Reddy 
 Department of Reproductive Medicine, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Porur, Chennai, Tamil Nadu, India

Correspondence Address:
Monna Pandurangi
Department of Reproductive Medicine, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University, Ramachandra Nagar, Porur, Chennai - 600 116, Tamil Nadu
India

CONTEXT: Ovulation induction in patients with hypogonadotropic hypogonadism (HH) is a challenge to the treating physician. The threshold for ovarian response in HH may differ substantially from that of normal patients. To reach that threshold levels of follicle stimulating hormone, in a step-up protocol longer duration of stimulation is required in some cases so as to prevent multiple pregnancy and to eliminate the risk of ovarian hyperstimulation syndrome. AIM: To evaluate the duration of stimulation, quality of oocytes, and embryo, and the pregnancy outcome in the assisted reproductive technology (ART) cycles in patients with HH. MATERIALS AND METHODS: Over the period of 4 years, we had 14 patients with HH in whom 21 cycles of ovulation induction were done. Of these 7 patients underwent oocyte retrieval and intracytoplasmic sperm injection (ICSI). We present a retrospective study of these 7 patients who underwent ART to evaluate the duration of stimulation, quality of oocytes and embryo, and the pregnancy outcome. RESULTS: In the study group on ovulation induction with gonadotropins, only one patient had the duration of stimulation of the standard 12 days, the remaining 6 patients took ≥12 days to respond to stimulation (maxium being 54 days). Mean ET in these patients was 8.9 mm. Six patients had >70% good quality MII oocytes. One patient responded poorly and had only 2 good quality MII oocytes (50%). After ICSI procedure, resultant embryos were of grade 1 and 2 in all the patients irrespective of the duration of stimulation. Fertilization rate in these patients was 85% (except in one 50% fertilization rate), and the cumulative pregnancy rate was 68.6%. CONCLUSION: In the patients with HH the quality of oocytes and embryos, and the pregnancy rate is not affected even if the duration of stimulation is prolonged.


How to cite this article:
Pandurangi M, Tamizharasi M, Reddy N S. Pregnancy outcome of assisted reproductive technology cycle in patients with hypogonadotropic hypogonadism.J Hum Reprod Sci 2015;8:146-150


How to cite this URL:
Pandurangi M, Tamizharasi M, Reddy N S. Pregnancy outcome of assisted reproductive technology cycle in patients with hypogonadotropic hypogonadism. J Hum Reprod Sci [serial online] 2015 [cited 2022 Jun 28 ];8:146-150
Available from: https://www.jhrsonline.org/article.asp?issn=0974-1208;year=2015;volume=8;issue=3;spage=146;epage=150;aulast=Pandurangi;type=0