Journal of Human Reproductive Sciences

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 8  |  Issue : 4  |  Page : 224--229

Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy


Ymer Mekaj1, Shefqet Lulaj2, Fetie Daci4, Naser Rafuna2, Ermira Miftari2, Hakif Hoxha1, Xhemile Sllamniku4, Agon Mekaj3 
1 Institute of Pathophysiology, Faculty of Medicine, University of Prishtina; Department of Hemostasis and Thrombosis, National Blood Transfusion Center of Kosovo, Prishtina, Kosovo
2 Clinic of Gynecology and Obstetrics, University Clinical Center of Kosovo, Prishtina, Kosovo
3 Clinic of Neurosurgery, Faculty of Medicine, University of Prishtina, Prishtina 10000, Kosovo

Correspondence Address:
Agon Mekaj
Faculty of Medicine, University of Prishtina. Rrethi i spitalit p.n. Prishtina 10000
Kosovo

Context: Several studies have reported that thrombophilia is responsible for recurrent pregnancy loss (RPL). AIMS: The aim of this study was to evaluate the prevalence and role of inherited thrombophilia in early pregnancy loss, specifically in the first trimester. Materials and Methods: A total of 104 women (patients) with a history of two or more miscarriages during the first trimester of pregnancy and 110 women (controls) who had experienced two or more births without a miscarriage were included in this study. In both groups, we determined the biological activities of antithrombin III (ATIII) and protein C (PC) using the chromogenic method and the biological activity of protein S (PS) and the activated protein C resistance (APCR) were examined using a clotting method. Results: In the patient group, deficiencies of ATIII, PC, and PS were detected in 3 (2.88%), 4 (3.85%), and 6 (5.77%) cases, respectively. In the control group, ATIII (0%) deficiencies were not detected, and deficiencies for PC (0.9%) and PS (0.9%) were each detected in 1 patient. APCR was detected in 9 patients (8.65%) and 4 control subjects (3.63%). Conclusion: Based on our results, we can conclude that thrombophilia is a causal factor for miscarriages in the first trimester of pregnancy, although there are the conflicting data in the literature.


How to cite this article:
Mekaj Y, Lulaj S, Daci F, Rafuna N, Miftari E, Hoxha H, Sllamniku X, Mekaj A. Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy.J Hum Reprod Sci 2015;8:224-229


How to cite this URL:
Mekaj Y, Lulaj S, Daci F, Rafuna N, Miftari E, Hoxha H, Sllamniku X, Mekaj A. Prevalence and role of antithrombin III, protein C and protein S deficiencies and activated protein C resistance in Kosovo women with recurrent pregnancy loss during the first trimester of pregnancy. J Hum Reprod Sci [serial online] 2015 [cited 2022 Oct 3 ];8:224-229
Available from: https://www.jhrsonline.org/article.asp?issn=0974-1208;year=2015;volume=8;issue=4;spage=224;epage=229;aulast=Mekaj;type=0