Journal of Human Reproductive Sciences

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 14  |  Issue : 3  |  Page : 300--306

Pregnancy in older women: Analysis of outcomes in pregnancies from donor oocyte In- vitro fertilization


James A Osaikhuwuomwan1, Michael E Aziken2 
1 Department of Obstetrics and Gynaecology, College of Medical Sciences, University of Benin, Benin-City, Nigeria
2 Department of Obstetrics and Gynaecology, College of Medical Sciences, University of Benin; Assisted Reproduction and Endoscopy Unit, Graceland Medical Centre, Benin-City, Nigeria

Correspondence Address:
Dr. Michael E Aziken
Department of Obstetrics and Gynaecology, University of Benin
Nigeria

Background: As the number of older women attempting to conceive through donor oocyte-in vitro fertilization (DO-IVF) rises, their safety in pregnancy needs to be judiciously considered. Aims: This study aims to review the obstetric and perinatal outcomes of pregnancies achieved by DO-IVF. Study Setting and Design: A retrospective study design conducted at a private health facility with services for assisted reproduction and gynecologic endoscopy. Methods: A retrospective comparative study of all pregnancies achieved using DO-IVF and that using Self oocyte In-vitro fertilization (SO-IVF) treatment over a 3 years' period was performed. Statistical Analysis: Comparative analysis of demographic variables, major obstetric, and perinatal complications was done with Chi-square test and Student's t-test as appropriate. Regression analysis was done to determine a significant predictor variable for pregnancy and delivery outcome. The significance level was set at P < 0.05. Results: A total of 343 completed IVF treatment cycles was reviewed; there were 238 DO-IVF and 105 SO-IVF cycles, with clinical pregnancy rate of 41.6% and 37.1%, respectively. The DO-IVF group was significantly older than the SO-IVF group (46.1 years vs. 34.1 years, P < 0.001). Major obstetric complications identified, were hypertensive disorders in pregnancy (23.9%), preterm labor (16.7%), antepartum hemorrhage (11.6%). There was no statistically significant difference between the two groups in terms of obstetric complications and adverse maternal or perinatal outcomes. There were 97 (77.6%) singleton and 28 (22.4%) multiple pregnancies. Pregnancy complications were significantly associated with fetal plurality, P < 0.001. Multiple pregnancy had higher odds of experiencing adverse perinatal 4.96 (1.95–12.58) and maternal 7.16 (2.05–25.03) outcomes compared to singleton pregnancies, P < 0.001. Conclusion: Key obstetric outcomes did not differ between DO or SO IVF achieved pregnancy. Even for older women, satisfactory outcomes can be expected for pregnancies achieved by DO-IVF. It is, however, instructive that for multiple pregnancies, obstetricians should institute appropriate surveillance strategies during pregnancy and delivery period and also to develop institutional capacity for quality neonatal care.


How to cite this article:
Osaikhuwuomwan JA, Aziken ME. Pregnancy in older women: Analysis of outcomes in pregnancies from donor oocyte In- vitro fertilization.J Hum Reprod Sci 2021;14:300-306


How to cite this URL:
Osaikhuwuomwan JA, Aziken ME. Pregnancy in older women: Analysis of outcomes in pregnancies from donor oocyte In- vitro fertilization. J Hum Reprod Sci [serial online] 2021 [cited 2023 Feb 7 ];14:300-306
Available from: https://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=3;spage=300;epage=306;aulast=Osaikhuwuomwan;type=0