Journal of Human Reproductive Sciences

CASE REPORT
Year
: 2021  |  Volume : 14  |  Issue : 3  |  Page : 321--324

Severe ovarian hyperstimulation syndrome in a case of nonmutated recurrent genuine empty follicle syndrome


Sumina Mannur1, Talha Jabeen2, Mohd Abdul Khader2, Ramanachary Namoju3, Lendale Sai Shakti Rao2 
1 Department of Obstetrics and Gynecology, Angels Fertility Center, Hyderabad, Telangana, India
2 Department of Pharmacology and Pharmacy Practice, Bhaskar Pharmacy College, Jawaharlal Nehru Technical University, Hyderabad, Telangana, India
3 Department of Pharmacology, GITAM University, Vishakhapatnam, Andhra Pradesh, India

Correspondence Address:
Dr. Sumina Mannur
Department of Obstetrics and Gynecology, Angels Fertility Center, Hyderabad - 500 008, Telangana
India

Empty follicle syndrome (EFS) is a rare event in which no oocytes are retrieved from apparently normal growing follicles with normal steroidogenesis despite meticulous follicular aspiration in assisted reproductive technology (ART) cycles. EFS is mainly of two types, genuine EFS and false EFS. Here, we report a case of a 24-year-old woman presenting with primary infertility with normal ovarian reserve and regular menstrual cycles, husband having severe “oligo-astheno-teratozoospermia,” and planned for ART treatment. We could not retrieve any oocytes in successive cycles despite optimum human chorionic gonadotropin (hCG) levels on the day of oocyte retrieval and using different management protocols mentioned until now in the literature. The whole genomic analysis was found to be normal (46, XX). Further, the patient had experienced severe ovarian hyperstimulation syndrome (OHSS) after the second cycle of ovarian stimulation despite no luteal hCG support. We were ineffectual to find the cause of recurrent EFS in this patient and therefore counseled the patient for donor oocytes. This case highlights the difficulty in treating genuine EFS patients and the need for monitoring serum estradiol levels during ovarian stimulation to prevent another serious complication of OHSS.


How to cite this article:
Mannur S, Jabeen T, Khader MA, Namoju R, Rao LS. Severe ovarian hyperstimulation syndrome in a case of nonmutated recurrent genuine empty follicle syndrome.J Hum Reprod Sci 2021;14:321-324


How to cite this URL:
Mannur S, Jabeen T, Khader MA, Namoju R, Rao LS. Severe ovarian hyperstimulation syndrome in a case of nonmutated recurrent genuine empty follicle syndrome. J Hum Reprod Sci [serial online] 2021 [cited 2022 Aug 19 ];14:321-324
Available from: https://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=3;spage=321;epage=324;aulast=Mannur;type=0