Journal of Human Reproductive Sciences

REVIEW ARTICLE
Year
: 2021  |  Volume : 14  |  Issue : 4  |  Page : 340--349

Oocyte cryopreservation - current scenario and future perspectives: A narrative review


Hrishikesh D Pai1, Rashmi Baid1, Nandita P Palshetkar1, Arnav Pai2, Rishma D Pai3, Rohan Palshetkar4 
1 Department of Reproductive Medicine, Lilavati Hospital and Research Centre, Mumbai, India
2 Department of Obstetrics & Gynecology, D Y Patil Medical College and Hospital, Mumbai, Maharashtra, India
3 Department of Obstetrics & Gynaecology, Lilavati Hospital, Mumbai, Maharashtra, India
4 Department of Reproductive Medicine, H N Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Rashmi Baid
Lilavati Hospital and Research Center, Mumbai, Maharashtra
India

Oocyte cryopreservation is a boon for women undergoing assisted reproductive technology. With the evolution in the technique of cryopreservation over the last three decades, there has been an exponential rise in the number of oocyte cryopreservation cycles for diverse indications. Apart from cancer patients, it has also been promoted as a mode of fertility insurance to overcome the age-related decline in fertility as well as post-surgical decline following endometriosis surgery. The objective of the review is to evaluate its clinical applications, ideal age at freezing, optimal oocyte number, freezing method of choice, efficacy, safety and recent advances. In the last decade, vitrification has surpassed slow freezing for oocyte cryopreservation. Although closed system of vitrification provides the aseptic environment, open vitrification is commonly followed in practice. Early to mid-thirties is a reasonable age group for planned oocyte cryopreservation, although it might be recommended at a younger age, in patients with diminished ovarian reserve. The patients should be motivated to preserve around 14–20 mature oocytes for successful live birth. Various studies have shown comparable fertilisation and pregnancy rates between Intracytoplasmic sperm injection with fresh and frozen-thawed oocytes. The available evidence has shown no increase in the incidence of congenital abnormalities in babies born through vitrified oocytes. In the future, image analysis using artificial intelligence, and spindle visualisation using poloscope may further enhance the outcome of oocyte cryopreservation.


How to cite this article:
Pai HD, Baid R, Palshetkar NP, Pai A, Pai RD, Palshetkar R. Oocyte cryopreservation - current scenario and future perspectives: A narrative review.J Hum Reprod Sci 2021;14:340-349


How to cite this URL:
Pai HD, Baid R, Palshetkar NP, Pai A, Pai RD, Palshetkar R. Oocyte cryopreservation - current scenario and future perspectives: A narrative review. J Hum Reprod Sci [serial online] 2021 [cited 2022 Sep 26 ];14:340-349
Available from: https://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=4;spage=340;epage=349;aulast=Pai;type=0