Journal of Human Reproductive Sciences

CASE REPORT
Year
: 2021  |  Volume : 14  |  Issue : 4  |  Page : 446--449

Successful application of combined autologous bone marrow-derived stem cells and platelet-rich plasma in a case of severe asherman syndrome and subsequent in vitro fertilization conception


Sunita Tandulwadkar, Sneha Mishra, Shruti Gupta 
 Ruby Hall Clinic, Pune, Maharashtra¸, India

Correspondence Address:
Dr. Sunita Tandulwadkar
SOLO CLINIC C 50/51, Sharadaram Park, Next to Crowne Plaza Hotel, Opp Ruby Hall Clinic, Pune - 411 001, Maharashtra
India

The application of stem cells in infertility is still experimental. Thin endometrium is an important cause of cancelled or less successful frozen embryo transfer cycles. Clinically, numerous strategies have been adopted to promote endometrial regeneration including extended oestrogen administration, low-dose aspirin, pentoxifylline, tocopherol, vaginal sildenafil citrate and intrauterine perfusion with granulocyte colony-stimulating factor. However, even with the use of these therapies, the endometrium in some patients still remains unresponsive. Latest research shows that autologous bone marrow-derived stem cells (ABMDSCs) can be used for regeneration of damaged endometrium. We present a case report of patient with thin endometrium who was successfully treated with the combined use of ABMDSCs mixed with platelet-rich plasma, leading to successful in vitro fertilization conceived pregnancy. Patient consent and due ethical clearance were taken before starting the procedure.


How to cite this article:
Tandulwadkar S, Mishra S, Gupta S. Successful application of combined autologous bone marrow-derived stem cells and platelet-rich plasma in a case of severe asherman syndrome and subsequent in vitro fertilization conception.J Hum Reprod Sci 2021;14:446-449


How to cite this URL:
Tandulwadkar S, Mishra S, Gupta S. Successful application of combined autologous bone marrow-derived stem cells and platelet-rich plasma in a case of severe asherman syndrome and subsequent in vitro fertilization conception. J Hum Reprod Sci [serial online] 2021 [cited 2022 May 27 ];14:446-449
Available from: https://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=4;spage=446;epage=449;aulast=Tandulwadkar;type=0